Tissue Seal

Tissue Seal was formed in 2002 by four individuals with a combined 120-plus years of experience in the medical device industry. In that same year, Tissue Seal partnered with B. Braun Europe to gain FDA regulatory clearance and bring Histoacryl® topical skin adhesives to the U.S. market. At that time, topical skin adhesives were considered a prescription drug and required pre-market approval for commercialization. The process took nearly four years to gain the necessary approvals for Histoacryl Clear and Histoacryl Blue, and the products entered commercial distribution in the United States in March 2007. Since that time, Tissue Seal has sold over 10 million ampoules of topical skin.

In December 2019, Tissue Seal entered into an agreement with B. Braun to take over sales and distribution of their suture product portfolio. Tissue Seal began marketing and distributing the full line of B. Braun closure products in the United States in 2020. Tissue Seal is ISO 13485 certified, and its distribution center is located in Ann Arbor, Michigan. In 2021, H.B. Fuller acquired Tissue Seal, LLC, and its product portfolio of skin closure technologies.